Dr. Josh Sharfstein, Vice Dean for Public Health Practice and Community Engagement at Johns Hopkins Bloomberg School of Public Health, provided a briefing of critical public health information on COVID-19 within the United States. Dr. Monica Schoch- Spana, Senior Scholar with the Johns Hopkins Center for Health Security and Senior Scientist in the Department of Environmental Health & Engineering at the Johns Hopkins University Bloomberg School of Public Health, presented guidance on the role of mayors in deploying vaccines. Herman B. "Dutch" Leonard, the George F. Baker Jr. Professor of Public Management at the Kennedy School, and Eliot I. Snider and Family Professor of Business Administration and Cochair of the Social Enterprise Initiative at Harvard Business School, facilitated a discussion on Leading Your City Effectively in a Rapidly Changing Context. Jorrit de Jong, Faculty Director of the Bloomberg Harvard City Leadership Initiative and Senior Lecturer in Public Policy and Management at Harvard Kennedy School, moderated the session.